Run to the marker and get the pickup truck.
Drive to the next marker.
Keep the back of the truck level with Madd Dogg as he drunkenly staggers back and forth. After a while he'll fall. Move so he lands in the boxes in the back of the truck.
Drive Madd Dogg to the hospital. Every time you crash he'll lose health, so be careful not to damage the vehicle too much.
Start this mission at The Four Dragons Casino in Las Venturas.
You start the mission freefalling from a plane down to Madd Dogg's mansion. Open your parachute as soon as possible and pull back so you can land on the helipad. If you miss it go around the back of the building, jump the fence and follow the building around to the ramp leading to the roof.
Once you're on the roof take out several waves of mobs. There's body armor next to the vents on the roof if you need it.
Once the roof is clear go down into the building.
Optional:
Oyster #49: is in the middle of the pool outside Madd Dogg's mansion.
Kill the mobs just inside the door and the few more that come running through, then make your way forward, carefully clearing out each side room. There's a health pickup and more body armor in the side rooms if you need them.
Once you've cleared to the end of the hallway go onto the balcony. Shoot the mobs below. More will turn up, shoot these.
Head downstairs and go left. Kill the mobs in this area and grab the health pickup in the kitchen if you need it.
Follow Big Poppa through the mansion, killing yet more of his mobs along the way.
When you get outside jump in the car and chase after Big Poppa's car, don't let him get too far ahead or you'll fail the mission. Drive-by his car until it explodes.
Get in the BF Injection and drive Madd Dogg to the marker.
When Loc flees, get in the hoverboat and chase him. Stay reasonably close to Loc, but you can't catch him yet, so don't worry too much about closing the gap.
Get in the Go Kart and continue chasing Loc. After a long chase Loc eventually stops and you're done.
Next: Side Mission: Taxi
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